FRAMEWORKS FOR ESTIMATING CAUSAL EFFECTS IN OBSERVATIONAL SETTINGS: COMPARING CONFOUNDER ADJUSTMENT AND INSTRUMENTAL VARIABLES

Frameworks for estimating causal effects in observational settings: comparing confounder adjustment and instrumental variables

Abstract To estimate causal effects, analysts performing observational studies in health settings utilize several strategies to mitigate bias due to confounding by indication.There are two broad classes of approaches for these purposes: use of confounders and instrumental variables (IVs).Because such approaches are largely characterized by untestab

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ON THE NOTION OF SYNERGY OF MONOCLONAL ANTIBODIES AS DRUGS

History of developing synergy between monoclonal antibodies, anti-tumor activity of monoclonal bostik roll-cote antibodies against tyrosine-kinases receptors EGFR/ErbB-1 and HER2/ErbB-2 as well as growth factor VEGF in various combinations are considered in the article.There were proposed hypotheses about potential molecular mechanisms underlay syn

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